Skin

Human Skin Xenografts

Epistem offers a chimeric model of engrafted human skin which can be used to:

  • Assess the efficacy and safety of novel therapeutic agents
  • Determine mechanism of action
  • Provide evidence for claims and patent support
  • Provide proof of concept biomarker data prior to clinical trials

Human Skin Xenograft Model Description

Following engraftment of human skin onto an immunocompromised host, novel therapeutic agents can be applied either topically or systemically for an average of 6 weeks. Samples can be taken at various time points for analysis.

Readouts

  • Histometric analysis
  • Protein expression
  • Gene expression

A transverse section through human skin, 6 weeks post s.c. engraftment onto host

A transverse section through human skin, 6 weeks post s.c. engraftment onto host

© 2013-17 Epistem Ltd. : : last modified: 04 Nov 2013

Epistem Ltd is a division of genedrive plc