Epistem offers a clinically relevant in vitro psoriasis model. Psoriasis is a common inflammatory disorder affecting the skin, characterised by inflamed and itchy plaques. An appropriate in vivo system for testing psoriasis novel therapeutic agents is lacking.
Psoriasis Model Description
Human primary keratinocytes are stimulated with a cocktail of pro-inflammatory cytokines to induce a gene expression profile which mimics that of psoriasis patients. The effects on gene expression in response to novel therapeutic agents can be assessed.
- Gene Expression
- Protein Expression