Inflammation

Collagen-Induced Arthritis

Epistem has developed an acute, collagen-induced arthritis model. This model exhibits many disease parameters representative of those observed in patients with rheumatoid arthritis.

Collagen-Induced Arthritis Model Description

Arthritis is established by a single injection of type II collagen. This leads to joint swelling and deformity. Disease onset is typically observed 3 weeks post immunisation. The effect of novel therapeutic agent administration on the penetrance and severity of disease can be quantified.

Primary Readouts

  • Clinical score
  • Joint swelling

Further Readouts

  • Histology and immunohistochemistry
  • Serology
  • Anti-collagen IgG responses
  • FACS analysis
  • Multiplex analysis of cytokines
  • Gene expression

H&E staining of the tarsus joint following immunisation with collagen

H&E staining of the tarsus joint following immunisation with collagen

© 2013-17 Epistem Ltd. : : last modified: 06 Dec 2013

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