Biodefense

Delayed Effects of Acute Radiation Exposure

The Delayed Effects of Acute Radiation Exposure (DEARE) take months and years to develop and typically manifest in the lung as pneumonitis and fibrosis. Epistem's extensive knowledge of the effect of radiation exposure has been applied to in vivo models of GI-DEARE. In the intestine these late effects are seen as changes in GI pathology (crypt and villus size and number, changes in proliferation and levels of fibrosis).

DEARE Model Description

X-ray irradiation is performed with bone marrow shielding where required. Full dosimetry of the 320kV source is also performed for each study run.

Readouts

  • Histology
  • Cytokine analysis by multiplex
  • Protein expression
  • Gene expression

Massons Trichrome stained intestine showing DEARE

Massons Trichrome stained intestine showing DEARE

© 2013-17 Epistem Ltd. : : last modified: 04 Nov 2013

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